Ketamine Infusion: The Superior Choice Over Esketamine Nasal Spray for treatment

By: Dr. David Lee


In recent years, ketamine has emerged as a revolutionary treatment for various chronic conditions, including depression, chronic pain, and certain psychiatric disorders. The debate often centers around two primary forms of administration: ketamine infusion and esketamine nasal spray. This blog post delves into the advantages of ketamine infusion, presenting it as the gold standard in treatment compared to esketamine nasal spray.  

What is Ketamine Infusion?

Ketamine infusion involves administering a specific dose of ketamine intravenously. This method has been extensively studied and is renowned for its effectiveness and safety. It allows for precise dosing, immediate absorption into the bloodstream, and offers a controlled environment for treatment.

Esketamine Nasal Spray: An Overview

Esketamine, a derivative of ketamine, is typically administered as a nasal spray. Approved by the FDA for treatment-resistant depression, it's a more recent addition to the array of ketamine-based treatments. While it offers the convenience of self-administration and non-invasiveness, there are notable differences when compared to ketamine infusion.

Comparative Analysis: Infusion vs. Nasal Spray

1. Dosage Control and Precision:

 Ketamine infusion allows for meticulous dosage control, tailored to each individual's needs. In contrast, esketamine nasal spray provides a fixed dose, which may not be suitable for all patients.

2. Bioavailability and Effectiveness: 

The intravenous route in ketamine infusion ensures almost 100% bioavailability, leading to more predictable and potent effects. Esketamine nasal spray’s effectiveness can be variable due to factors like nasal congestion or improper administration.

3. Rapid Onset of Action: 

Patients undergoing ketamine infusion often report quicker symptom relief compared to the nasal spray. This is crucial for individuals seeking immediate relief from severe symptoms.

4. Safety and Monitoring: 

Infusion treatments are conducted in a controlled setting under medical supervision, ensuring immediate response to any adverse effects. In contrast, the self-administered nature of esketamine nasal spray lacks this level of safety monitoring.

5. Long-term Efficacy: 

Studies suggest that ketamine infusion may offer longer-lasting relief compared to esketamine nasal spray, making it a more effective long-term treatment option.


While both ketamine infusion and esketamine nasal spray are significant advancements in treatment, the infusion stands out as the gold standard. Its precision, effectiveness, rapid action, and safety profile make it a superior choice for patients seeking reliable and robust treatment outcomes.

Remember, always consult with a healthcare professional before considering any treatment options. Ketamine infusion therapy should be administered by trained professionals in a clinical setting to ensure the highest standards of care and safety.

* All information subject to change. Images may contain models. Individual results are not guaranteed and may vary.